• Researcher Profile

    Elgene Lim, MD, PhD

     
    Elgene Lim, MD, PhD
     
    Instructor in Medicine

    Center/Program

    Breast Oncology

    Office phone: 617-632-5620
    Fax: 617-632-1930
    Email: elgene_lim@dfci.harvard.edu

    Preferred contact method: email

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    Research Departments

    Medical Oncology

    Medical Oncology/Molecular and Cellular

    Interest

    Clinical Trials

    Area of Research

    Translational research in Breast Cancer


    Dana-Farber Cancer Institute
    450 Brookline Avenue
    Yawkey 1242
    Boston, MA 02215

    Biography

    Dr. Lim received his medical training from the University of Melbourne, Australia, in 1995. He spent 3 years in the military, and returned to complete his Internal Medicine residency at the Royal Melbourne Hospital and a fellowship in Medical Oncology with the Royal Australasian College of Physicians. He subsequently embarked on a Ph.D. in Molecular Biology at the Walter & Eliza Hall Institute of Medical Research where his studies focused on the mammary epithelial cell hierarchy, aberrant changes in the mammary glands of BRCA1 germline mutation carriers, and the development of patient-derived breast cancer xenografts in mice for the developing of novel therapies.

    In 2010, he came to the Dana-Farber Cancer Institute as a post-doctoral fellow under the mentorship of Eric Winer and Myles Brown. In 2012, he was admitted to the faculty of Dana-Farber as an instructor in medicine.

    His translation research focus is in the field of breast cancer, and includes:
    1) Hormonal signaling in normal breast tissue and breast cancer. Using patient-derived tissue, his studies focus on the genetic and epigenetic changes in mammary cells that occur during cancer development and progression.
    2) The evaluation of novel breast cancer therapies and biomarkers using patient-derived breast cancer xenografts.
    3) Understanding the predisposing factors leading to breast cancer in BRCA1 and BRCA2 mutation carriers.

    Recent Awards

    • Claudia Barr Adams Award, 2013
    • Women's Cancer Program Research Award, 2013
    • National Health and Medical Research Council of Australia Postdoctoral Fellowship, 2011
    • Fulbright Scholarship, 2010
    • Women's Cancer Program Research Award , 2010
    • Best PhD Seminar, Walter & Eliza Hall Institute of Medical Research, 2009
    • Edith Moffatt Award, Walter & Eliza Hall Institute of Medical Research, 2009
    • JJ Billings Fellowship, Royal Australasian College of Physicians, 2009
    • Best Oral Presentation, Clinical Oncological Society of Australia Annual Meeting, 2008
    • Best Oral Presentation, Melbourne Health Research Symposium, 2008
    • Breast Cancer Excellence Travel Award, New South Wales Breast Cancer Institute, 2008
    • Early Career Bench and Bedside Collaboration Award, Victorian Cancer Agency, 2008
    • Post Graduate Research Award, Glaxo Smith Kline , 2008
    • Director's Art in Science Prize, Walter & Eliza Hall Institute of Medical Research, 2007
    • Post Graduate Reseach Award, Australian Stem Cell Center, 2007
    • Tumor Targeting Fellowship, Clinical Oncological Society of Australia , 2007
    • White/Zaal Post Graduate Scholarship, National Breast Cancer Foundation of Australia, 2006
    • Best Knowledge, School of Militray Medicine, Singapore Armed Forces, 1997
    • M Patrick Callinan Academic Prize, St. Marry's College, University of Melbourne, 1990

    Research

    Translational research in Breast Cancer

    The primary focus of my research is in the area of breast cancer. A common theme is the use of patient-derived breast tissue, both normal and cancer, in order to better understand and more accurately model the behaviour of these cells in patients.

    The current areas of my research include:
    1) Hormonal signaling in normal breast tissue and breast cancer. Using patient-derived tissue, our studies focuses on the genetic and epigenetic changes in mammary cells that occur during cancer development and progression.

    2) The evaluation of novel breast cancer therapies and biomarkers using patient-derived breast cancer xenografts.

    3) Understanding the predisposing factors leading to breast cancer in BRCA1 and BRCA2 mutation carriers.


     

    Select Publications

    • Lim E, Roberts L, Wicks I. Intracardiac thrombosis complicating antiphospholipid antibody syndrome: Intern Med J. 2004;34(3):135-7.
    • Lim E, Johns J, McLaughlin S, Faragher I, Skinner I, Chao M, Gibbs P. Subsite-specific colorectal cancer in diabetic and non-diabetic patients. Cancer Epidemiology, Prevention and Biomarkers 2005;14(6):1579-82.
    • Lim E, Browning J, MacGregor D, Davis ID, Cebon JS. Antigen expression in desmoplastic melanoma; a comparison of cancer testis antigen with differentiation antigen expression. Melanoma Research 2006;16(4):347-55.
    • Rodrigues J, Lim E, McLaughlin S, Faragher I, Skinner I, Chao M, Chapman M, Gibbs P. The influence of language spoken on colorectal cancer diagnosis and management. ANZ J Surg 2006; 76:671-3.
    • Lim E, Thomson BNJ ,Heinz S,Chao M, Gunawardana D, Gibbs P. Optimising the approach to patients with potentially resectable liver metastases from colorectal cancer. ANZ J Surg. 2007; 77(11):941-7.
    • Lim E, Rosenthal M. Diagnosing Cancer: Changing patterns of care. Intern Med J. 2007;37(2):124-6.
    • Lim E, Vaillant F, Wu D, Forrest N, Pal B, Hart A, Asselin-Labat ML, Gyorki DE, Ward T, Partanen A, Feleppa F, Huschtscha L, Thorne H, kConFab, Fox SB, Yan M, French JD, Brown MA, Smyth GK, Visvader JE, Lindeman GJ. Aberrant luminal progenitors as a likely target population for basal tumor development in BRCA1 mutation carriers. Nature Medicine 2009;15(8):842-4.
    • Lim E, Wu D, Pal B, Bouras T, Asselin-Labat ML, Vaillant F, Yagita H, Lindeman GJ, Smyth GK, Visvader JE. Transcriptome analyses of mouse and human mammary cell subpopulations reveal multiple conserved genes and pathways. Breast Cancer Research 2010;12(2):R21.
    • Wu D, Lim E, Vaillant F, Asselin-Labat ML, Visvader JE, Smyth GK. ROAST: rotation gene set tests for complex microarray experiments. Bioinformatics 2010;26(17):2176-82. 
    • Ni M, Chen YW, Lim E, Bailey ST, Imai Y, Liu XS, Brown M. Targeting Androgen Receptor in Estrogen Receptor-Negative Breast Cancer. Cancer Cell 2011;20(1):119-31.
    • Oakes SR, Vaillant F, Lim E, Lee L, Breslin K, Feleppa F, Deb S, Takano E, Fox SB, Generali D, Strasser A, Huang DCS, Visvader JE, Lindeman GJ. The BH3-mimetic ABT-737 sensitizes BCL-2 expressing breast cancers to chemotherapy, implicating BCL-2 as a predictive biomarker. PNAS 2011:109(8);2766-2771.
    • Lim E & Winer EP. Will preoperative trials change future clinical practice? Clinical Investigation 2011;1(1):59-73.
    • Lim E & Winer EP. Current challenges in HER2-positive breast cancer. ASCO Educational Book 2011;14-20.
    • Lim E & Winer EP. Adjuvant chemotherapy in luminal breast cancers. Breast 2011;20 S3:S128-31.
    • Lim E & Lin NU. New insights and emerging therapies in breast cancer brain metastases. Oncology 2012;26(7):652-9.
    • Lim E, Metzger O, Winer EP. The natural history of luminal breast cancer. Oncology 2012;26(8);688-94.
    • Lim E, Ni Min, Hazra A, Tamini R, Brown M. Elucidating the role of Androgen receptors and breast cancer. Clinical Investigation 2012:2(10);1003-11.
    • Shen R, Zhou A, Kim E, Lim E, Habelhah H, Hahn W. IKKε phosphorylates TRAF2 to promote mammary epithelial cell transformation. Mol Cell Biol. 2012 Dec;32(23):4756-68.
    • Tichy J, Lim E, Anders CK. Adolescent and Young Adult Breast Cancer: A Review with a Focus on Biology. J Natl Cancer Inst.
    • Ni M, Chen YW, Fei T, Li D, Lim E, Liu XS, Brown M. Amplitude Modulation of Androgen Signaling by c-MYC. Genes and Development. Accepted 2013.
    • Buchwalter G, Hickey MM, Cromer A, Selfors LM, Gunawardane RN, Frishman J, Jeselsohn R, Lim E, Fu X, Schiff R, Brown M, Brugge JS. PDEF Promotes Luminal Differentiation 1 and Acts as a Survival Factor for ER Positive Breast Cancer Cells. Cancer Cell. Accepted 2013.

    Trainees

    • Chi, David, B.S.
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