Research Department

Biostatistics and Computational Biology

Recent Awards

• University Graduate Fellowship, Award given by University of Maryland at College Park, 1994-1996
• Jiu-Zhang Mathematics Award (best graduating student), Award given by Department of Mathematics, Peking University, 1992

Select Publications

• Yuan G, Hunt BR. Optimal orbits of hyperbolic systems. Nonlinearity 1999;12(4):1207-1224.
  
  Yuan GC, Yorke JA, Carroll TL, Ott E, Pecora LM. Testing whether two chaotic one dimensional processes are dynamically identical. Physical Review Letters 2000;85(20):4265-4268.
  
  Haller G, Yuan G. Lagrangian coherent structures and mixing in two-dimensional turbulence. Physica D 2000;147(3-4):352-370.
  
  Yuan GC, Yorke JA. An open set of maps for which every point is absolutely nonshadowable. Proceedings of the American Mathematical Society 2000;128(3):909-918.
  
  Yuan GC, Yorke JA. Collapsing of chaos in one dimensional maps. Physica D 2000;36(1-2):18-30.
  
  Yuan GC, Nam K, Antonsen TM Jr, Ott E, Guzdar PN. Power spectrum of passive scalars in two dimensional chaotic flows. CHAOS 2000;10(1) (Focus issue: chaotic kinetics and transport):39-49.
  
  Yuan GC, Pratt LJ, Jones CKRT. Barrier destruction and Lagrangian predictability at depth in a meandering jet. Dynamics of Atmospheres and Oceans 2002;35(1):41-61.
  
  Yuan GC, Pratt LJ, Jones CKRT. Cross-jet Lagrangian transport and mixing in a 2 layer model. Journal of Physical Oceanography 2004;34(9):1991-2005.
  
  Yuan GC, Lozier MS, Pratt LJ, Jones CKRT, Helfrich KR. Estimating the predictability of an oceanic time series using linear and nonlinear methods. Journal of Geophysical Research 2004;109(C08):C08002.
  
  Yuan GC, Liu YJ, Dion MF, Slack MD, Wu LF, Altschuler SJ, Rando OJ. Genome-scale identification of nucleosome positions in S. Cerevisiae. Science 2005;309(5734):626-630 (commented by Jean Marx, Nucleosomes help guide yeast gene activity, Science, 17 June 2005: p.1724).
  
  Yuan GC*, Ma P*, Zhong W, Liu JS. Statistical assessment of the global regulatory role of histone acetylation in Saccharomyces cerevisiae. Genome Biol 2006;7(8):R70.
  
  Yang SC, Cai M, Kalnay E, Rienecker M, Yuan G, Toth Z. ENSO bred vectors in coupled ocean-atmosphere General Circulation Models. Journal of Climate 2006;19(8):1422-1436.
  
  Dennis JH, Fan HY, Reynolds SM, Yuan G, Meldrim JC, Richter DJ, Peterson DG, Rando OJ, Noble WS, Kingston RE. Independent and complementary methods for large-scale structural analysis of mammalian chromatin. Genome Res 2007;17(6):928-39.
  
  Yuan GC, Liu JS. Genomic sequence is highly predictive of local nucleosome depletion. PLoS Comput Biol 2008;4(1):e13. PMCID:PMC2211532.
  
  Shen X., Liu Y, Hsu J, Fujiwara Y, Kim J, Mao X, Yuan GC, Orkin SH. EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining the identity and pluripotency of mouse embryonic stem cells. Mol Cell 2008;32(4):491-502. PMCID:PMC2630502.
  
  Di Ges V, Lo Bosco G, Pinello L, Yuan GC, Corona DFV. A multi-layer method to study genome-scale positions of nucleosomes. Genomics 2009;93(2):140-5.
  
  Yuan GC. Targeted recruitment of histone modifications in humans predicted by genomic sequences. J Comput Biol 2009;16(2):341-355.
  
  Wippo CJ, Krstulovic BS, Ertel F, Musladin S, Blaschke D, Strzl S, Yuan GC, Hrz W, Korber P, Barbaric S. Differential cofactor requirements for histone eviction from two nucleosomes at the yeast PHO84 promoter are determined by intrinsic nucleosome stability. Mol Cell Biol 2009;29(11):2960-81. PMCID:PMC2682004.
  
  Lantermann AB, Straub T, Strlfors A, Yuan GC, Ekwall K, Korber P. Evolutionary plasticity of nucleosome positioning mechanisms in yeasts. Submitted.
  
  Shen X, Kim W, Fujiwara Y, Liu Y, Mysliwiec MR, Yuan GC, Lee Y, Orkin SH. Jumonji modulates Polycomb activity and self-renewal versus differentiation of stem cells. Submitted.

Trainees

• Shao, Zhen, PhD
• Liu, Yingchun, PhD
• Mar, Jessica, PhD