• Researcher Profile

    Guo-Cheng Yuan, PhD

    Guo-Cheng Yuan, PhD
    Associate Professor of Computational Biology and Bioinformatics

    Office phone: 617-582-8532
    Email: gcyuan@jimmy.harvard.edu
    Website: Yuan Lab

    Preferred contact method: email

    450 Brookline Avenue
    CLS 11026
    Boston, MA 02215

    Recent Awards

    • Milton Award, 2011
    • HSPH Career Incubator Award, 2010
    • Claudia Adams Barr Award, 2008

    Select Publications

    • Yuan GC, Liu YJ, Dion MF, Slack MD, Wu LF, Altschuler SJ, Rando OJ. Genome-scale identification of nucleosome positions in S. Cerevisiae. Science 2005;309(5734):626-630 (commented by Jean Marx, Nucleosomes help guide yeast gene activity, Science, 17 June 2005: p.1724).  
    • Yuan GC, Ma P, Zhong W, Liu JS.  Statistical assessment of the global impact of histone acetylation on gene expression in Saccharomyces cerevisiae.  Genome Biology 2006;7:R70.
    • Yuan GC, Liu JS. Genomic sequence is highly predictive of local nucleosome depletion. PLoS Comput Biol 2008;4(1):e13. 
    • Shen X., Liu Y, Hsu J, Fujiwara Y, Kim J, Mao X, Yuan GC, Orkin SH. EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining the identity and pluripotency of mouse embryonic stem cells. Mol Cell 2008;32(4):491-502. 
    • Shen X, Kim W, Fujiwara Y, Liu Y, Mysliwiec MR, Yuan GC, Lee Y, Orkin SH. Jumonji modulates Polycomb activity and self-renewal versus differentiation of stem cells. Cell 2009 Dec 24;139(7):1303-14.
    • Lantermann AB, Straub T, Strålfors A, Yuan GC, Eckwall K, Korber P. Schizosaccharomyces pombe genome-wide nucleosome mapping reveals positioning mechanisms distinct from Saccharomyces cerevisiae. Nature Structural and Molecular Biology 2010 Feb;17(2):251-7.
    • Liu Y, Shao Z, Yuan GC. Prediction of Polycomb target plasticity in mouse embryonic stem cells.  Genomics. 2010 Jul;96(1):17-26. 
    • Larson JL, Yuan GC. A hidden Markov model for detecting multi-gene chromatin domains. BMC Bioinformatics. 2010 Nov 12;11:557. 
    • Shao Z, Zhang Y, Yuan GC, Orkin SH, Waxman DJ. MAnorm: a robust model to quantitatively compare ChIP-Seq data sets. 2012 Mar 16;13(3):R16.
    • Xu J, Shao Z, Glass K, Bauer BE, Pinello L, van Handel B, Hou SY, Stamatoyannopoulos JA, Mikkola HKA, Yuan GC, Orkin SH.  Combinatorial assembly of developmental stage-specific enhancers controls gene expression programs during human erythropoiesis. Dev Cell. 2012 Oct 16;23(4):796-811. doi: 10.1016/j.devcel.2012.09.003. Epub 2012 Oct 4.
    • Glass K, Huttenhower C, Quackenbush J, Yuan GC. Passing messages between biological networks to refine predicted interactions. PLoS One. 2013 May 31;8(5):e64832.


    • Glass, Kimberly, PhD
    • Pinello, Luca, PhD
    • Marco, Eugenio, PhD
    • Saadatpour, Assieh, PhD
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