• Researcher Profile

    Alec Kimmelman, MD, PhD

     
    Alec Kimmelman, MD, PhD
     
    Physician

    Lecturer on Radiation Oncology, Part-Time, Harvard Medical School

    Office phone: 617-632-5195
    Fax: 617-632-6069
    Website: The Kimmelman Lab

    Preferred contact method: office phone
     
     

    Research Department

    Radiation Oncology

    Interest

    Gastrointestinal malignancies

    Area of Research

    Pancreatic cancer and other GI tumors

    Dana-Farber Cancer Institute
    Harvard Institute of Medicine
    4 Blackfan Circle, Suite 221
    Boston, MA

    Recent Awards

    • House Staff of the Year Award for Excellence in Patient Care, Mount Sinai School of Medicine at Cabrini Medical Center, 2004
    • Harold Elster Memorial Prize for Academic Standing, Mount Sinai School of Medicine, 2003

    Research

    Pancreatic cancer and other GI tumors

    Work in my laboratory focuses on understanding the pathogenesis of pancreatic adenocarcinoma. In this regard, we utilize genetically engineered mouse models of pancreatic cancer as well as cell culture based systems to study this deadly disease.
    One aspect of our research is to explore the response of these highly resistant tumors to chemotherapy and radiation to identify critical molecular pathways that dictate this response.
    Additionally, using a novel inducible genetic mouse model of pancreatic cancer, we are studying key genetic events involved in disease maintenance, progression, and metastasis.
    Furthermore, we are using our mouse and human models to identify novel therapeutic targets that may sensitize tumor cells to radiation and chemotherapy. Such findings are highly relevant to our understanding of pancreatic cancer and will provide highly needed, new therapeutic approaches.

    Trainees

    • Yang, Shenghong, PhD
    • Xiaoxu, Wang
    • Li, Yinghua, PhD
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