Alec Kimmelman, MD, PhD
Lecturer on Radiation Oncology, Part-Time, Harvard Medical School
Office phone: 617-632-5195
Website: The Kimmelman Lab
Preferred contact method: office phone
Area of ResearchPancreatic cancer and other GI tumors
Dana-Farber Cancer Institute
Harvard Institute of Medicine
4 Blackfan Circle, Suite 221
- House Staff of the Year Award for Excellence in Patient Care, Mount Sinai School of Medicine at Cabrini Medical Center, 2004
- Harold Elster Memorial Prize for Academic Standing, Mount Sinai School of Medicine, 2003
ResearchPancreatic cancer and other GI tumors
Work in my laboratory focuses on understanding the pathogenesis of pancreatic adenocarcinoma. In this regard, we utilize genetically engineered mouse models of pancreatic cancer as well as cell culture based systems to study this deadly disease.
One aspect of our research is to explore the response of these highly resistant tumors to chemotherapy and radiation to identify critical molecular pathways that dictate this response.
Additionally, using a novel inducible genetic mouse model of pancreatic cancer, we are studying key genetic events involved in disease maintenance, progression, and metastasis.
Furthermore, we are using our mouse and human models to identify novel therapeutic targets that may sensitize tumor cells to radiation and chemotherapy. Such findings are highly relevant to our understanding of pancreatic cancer and will provide highly needed, new therapeutic approaches.
- Yang, Shenghong, PhD
- Xiaoxu, Wang
- Li, Yinghua, PhD