Suzanne Gaudet, PhD
Office phone: 617-632-4269
Website: The Gaudet Lab
Preferred contact method: email
Area of ResearchTNF
450 Brookline Avenue
Boston, MA 02215
Suzanne Gaudet obtained her PhD in Biochemistry from Harvard University where she cloned and characterized PDZ-binding kinase, PBK, a mitotic kinase in human cells. She then joined Peter Sorger's laboratory at MIT as a postdoctoral associate for the launch of a project to study how TNF, EGF and insulin affect the cell death decision, using a systems approach. From 2003 to 2008, she worked as a research scientist and scientific coordinator at the Cell Decision Processes Center at MIT and Harvard. She is now assistant professor at the Department Genetics at Harvard Medical School and the Department of Cancer Biology at the Dana-Farber Cancer Insitute. Her research focuses on the quantitative understanding of how TNF-superfamily ligands control cell fate.
We study TNF-induced fate decisions in mammalian cells. TNF is particularly interesting because it induces both pro-survival and prodeath signals. Combining mathematical modeling and single-cell measurements, we exploit variability in response in a cell population to explore how these signals are integrated in time and space to control cell fate.
- 1. Spencer SL*, Gaudet S*, Albeck JG, Burke JM, Sorger PK. Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis. 2009; 459: 428-432. *equal contributors
2. Albeck JG, Macbeath G, White FM, Sorger PK, Lauffenburger DA, Gaudet S. Collecting and organizing systematic sets of protein data. Nat Rev Mol Cell Biol 2006; 7: 803-812. (Review)
3. Janes KA, Gaudet S, Albeck JG, Nielsen UB, Lauffenburger DA, Sorger PK. The response of human epithelial cells to TNF involves an inducible autocrine cascade. Cell 2006; 124: 1225-39.
4. Janes KA, Albeck JG, Gaudet S, Sorger PK, Lauffenburger DA, Yaffe MB. A systems model of signaling identifies a molecular basis set that predicts cytokine-induced apoptosis. Science 2005; 310: 1646-53.
5. Gaudet S, Janes KA, Albeck JG, Pace EA, Lauffenburger DA, Sorger PK. A compendium of signals and responses triggered by prodeath and prosurvival cytokines. Mol Cell Proteomics 2005; 4: 1569-1590.
6. El-Ali J, Gaudet S, Gunther A, Sorger PK, Jensen KF. Rapid cell stimulus and lysis in a microfluidic device with segmented gas-liquid flow. Anal Chem 2005; 77: 3629-36.
7. Janes KA, Kelly JR, Gaudet S, Albeck JG, Sorger PK, Lauffenburger DA. Cue-signal-response analysis of the TNF-induced apoptosis by partial least squares regression of dynamic multivariate data. J. Comput Biol 2004; 11: 544-61.
8. Lu. H, Gaudet S, Schmidt MA, Jensen KF. A microfluidic device for subcellular organelle sorting. Anal Chem 2004; 76: 5705-12.
9. Fritz J, Cooper EB, Gaudet S, Sorger PK. Manalis SR. Electronic detection of DNA by its intrinsic molecular charge. PNAS 2002; 99: 14142-6.
10. McLaughlin M, Hale R, Ellston D, Gaudet S, Lue RA, Viel A, (2002) The distribution and function of alternatively spliced insertions in hDlg. J Biol Chem 2002; 277: 6406-12.
11. Gaudet S, Branton D, Lue RA. Characterization of PBK-binding kinase, PBK, a mitotic kinase. PNAS 2000; 97: 5167-72.
- Lee, Robin