• Researcher Profile

    Xiaole Shirley Liu, PhD

    Xiaole Shirley Liu, PhD
    Director, Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute

    Professor of Biostatistics and Computational Biology, Harvard T.H. Chan School of Public Health

    Office phone: 617-632-2472
    Fax: 617-632-2444
    Email: xsliu@jimmy.harvard.edu
    Website: Liu Lab Website

    Preferred contact method: email

    Research Department

    Biostatistics and Computational Biology

    Area of Research

    Computational Cancer Epigenetics

    Dana-Farber Cancer Institute
    450 Brookline Avenue
    CLSB 11022
    Boston, MA 02215


    Dr. X. Shirley Liu graduated summa cum laude from Smith College double majoring in Biochemistry and Computer Science in 1997, and received PhD in Biomedical Informatics and PhD minor in Computer Science from Stanford University in 2002. She is now Professor at the Department of Biostatistics and Computational Biology at the Dana-Farber Cancer Institute and Harvard School of Public Health. She is the Director of the Center of Functional Cancer Epigenetics at Dana-Farber Cancer Institute, and an associate member of the Broad Institute. Her research focuses on computational cancer epigenetics, and developing algorithms for big cancer data integration and mining. 

    Recent Awards

    • Sloan Research Fellowship, 2008
    • Department of Defense Prostate Cancer Research Program New Investigator Award, 2006
    • Claudia Adams Barr Award for Innovative Basic Cancer Research, 2005


    Computational Cancer Epigenetics

    Through genome-wide transcription factor binding, chromatin dynamics, and gene expression profiles, we try to model the specificity and function of transcription factors, chromatin regulators and lncRNAs in tumor development, progression, drug response and resistance. 


    • Meyer, Clifford A.


    • Chen, Yiwen, PhD
    • Chongzhi, Zang, Ph.D.
    • Han, Xu, Ph.D.
    • Teng, Fei, Ph.D.
    • Wei, Li, Ph.D.
    • Graham, McVicker, Ph.D.
    • Tengfei, Xiao, Ph.D.
    • Peng, Jiang, Ph.D.
    • Chen-Hao, Chen, M.D.
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