• Researcher Profile

    Peter Sicinski, MD, PhD

     
    Peter Sicinski, MD, PhD
     
    Professor of Genetics, Harvard Medical School

    Office phone: 617-632-5005
    Fax: 617-632-5006
    Email: peter_sicinski@dfci.harvard.edu

    Preferred contact method: email
     
     

    Research Department

    Cancer Biology

    Area of Research

    Cell Cycle Machinery in Development and Cancer

    Dana-Farber Cancer Institute
    450 Brookline Avenue
    Smith 922A
    Boston, MA 02215

    Biography

    Dr. Sicinski received his MD and PhD from the Warsaw Medical School in Poland. He spent two years as a visiting scientist at the Medical Research Council in Cambridge, England, before becoming a postdoctoral fellow with Dr. Robert A. Weinberg at Massachusetts Institute of Technology.

    In 1997, Dr. Sicinski joined the faculty of Harvard and Dana-Farber Cancer Institute, where his research focuses on genes in the cell cycle machinery involved in normal cell development and cancer.

    Recent Awards

    • Foreign Member, Polish Academy of Sciences, 2005
    • Scholar of the Leukemia & Lymphoma Society, 2005
    • Scholar Leukemia & Lymphoma Society Award,, 2003
    • AACR-Gertrude B. Elion Cancer Research Award, 2002
    • Abbott Bioresearch Center Award, 2002

    Research

    Cell Cycle Machinery in Development and Cancer

    The cell cycle machinery is the ultimate recipient of oncogenic and mitogenic signals.

    Our laboratory studies the function of the cell cycle machinery at a molecular, cellular and organismal levels. We generated several knock-out and knock-in mouse strains which allow us to dissect the function of cell cycle proteins in normal development and in cancer formation or progression.

    We are also developing novel strains of mice that allow proteomic approaches to study the functions of cell cycle proteins (including cell cycle-independent functions) in various tissues of the living animal. The broad goal of these new directions is to combine the techniques of mouse germline manipulation with the new methods of proteome- and genome-wide analyses. We are also focusing on the functioning of the cell cycle machinery in various stem cell compartments.

    An important direction of our studies is to analyze the molecular functions of cell cycle proteins in human cancers.

    Investigators

    • Geng, Yan, MD, PhD

    Trainees

    • Odajima, Junko, PhD
    • Jirawatnotai, Siwanon, PhD
    • Choi, Yoon, PhD
    • Hydbring, Per, PhD
    • Michowski, Wojciech, PhD
    • Otto, Tobias, PhD
    • Liu, Lijun, MD
    • Wang, Haizhen, Ph.D.
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