• Researcher Profile

    Peter Sicinski, MD, PhD

     
    Peter Sicinski, MD, PhD
     
    Professor of Genetics, Harvard Medical School

    Office phone: 617-632-5005
    Fax: 617-632-5006
    Email: peter_sicinski@dfci.harvard.edu

    Preferred contact method: email
     
     

    Research Department

    Cancer Biology

    Area of Research

    Cell Cycle Machinery in Development and Cancer

    Dana-Farber Cancer Institute
    450 Brookline Avenue
    Smith 922A
    Boston, MA 02215

    Biography

    Dr. Sicinski received his MD and PhD from the Warsaw Medical School in Poland. He spent two years as a visiting scientist at the Medical Research Council in Cambridge, England, before becoming a postdoctoral fellow with Dr. Robert A. Weinberg at Massachusetts Institute of Technology.

    In 1997, Dr. Sicinski joined the faculty of Harvard and Dana-Farber Cancer Institute, where his research focuses on genes in the cell cycle machinery involved in normal cell development and cancer.

    Recent Awards

    • Foreign Member, Polish Academy of Sciences, 2005
    • Scholar of the Leukemia & Lymphoma Society, 2005
    • Scholar Leukemia & Lymphoma Society Award,, 2003
    • AACR-Gertrude B. Elion Cancer Research Award, 2002
    • Abbott Bioresearch Center Award, 2002

    Research

    Cell Cycle Machinery in Development and Cancer

    The cell cycle machinery is the ultimate recipient of oncogenic and mitogenic signals.

    Our laboratory studies the function of the cell cycle machinery at a molecular, cellular and organismal levels. We generated several knock-out and knock-in mouse strains which allow us to dissect the function of cell cycle proteins in normal development and in cancer formation or progression.

    We are also developing novel strains of mice that allow proteomic approaches to study the functions of cell cycle proteins (including cell cycle-independent functions) in various tissues of the living animal. The broad goal of these new directions is to combine the techniques of mouse germline manipulation with the new methods of proteome- and genome-wide analyses. We are also focusing on the functioning of the cell cycle machinery in various stem cell compartments.

    An important direction of our studies is to analyze the molecular functions of cell cycle proteins in human cancers.

    Select Publications

    • F. Bienvenu, S. Jirawatnotai, J.E. Elias, C.A. Meyer, K. Mizeracka, A. Marson, G.M. Frampton, M.F. Cole, D.T. Odom, J. Odajima, Y. Geng, A. Zagozdzon, M. Jecrois, R.A. Young, X.S. Liu, C.L. Cepko, S.P. Gygi, P. Sicinski. Transcriptional role of cyclin D1 in development revealed by a genetic-proteomic screen. Nature 463(7279), 374-8 (2010).
    • I. Kalaszczynska, Y. Geng, T. Iino, S. Mizuno, Y. Choi, I. Kondratiuk, D.P. Silver, D.J. Wolgemuth, K. Akashi, P. Sicinski. Cyclin A Redundant in fibroblasts, essential in hematopoietic and embryonal stem cells. Cell 138(2), 352-65 (2009).
    • Y. Geng, Y.M. Lee, M. Welcker, J. Swanger, A. Zagozdzon, J.D. Winer, J.M. Roberts, P. Kaldis, B.E. Clurman, P. Sicinski. Kinase-independent function of cyclin E. Mol. Cell 25, 127-39 (2007).
    • M.W. Landis, B.S. Pawlyk, T. Li, P. Sicinski, P.W. Hinds. Cyclin D1-dependent kinase activity in murine development and mammary tumorigenesis. Cancer Cell 9, 13-22 (2006).
    • K. Kozar, M. Ciemerych, V. Rebel, H. Shigematsu, A. Zagozdzon, E. Sicinska, Y. Geng, Q. Yu, S. Bhattacharya, R. Bronson, K. Akashi, P. Sicinski. Mouse development and cell proliferation in the absence of D-cyclins. Cell 118, 477-491 (2004).
    • Y. Geng, Q. Yu, E. Sicinska, M. Das, J.E. Schneider, S. Bhattacharya, W.M. Rideout, R.T.Bronson, H. Gardner, P. Sicinski. Cyclin E ablation in the mouse. Cell 114, 431-443 (2003).
    • Q. Yu, E. Sicinska, Y. Geng, M. Ahnstrom, A. Zagozdzon, Y. Kong, H. Gardner, H. Kiyokawa, L.N. Harris, O. Stal, P. Sicinski. Requirement for CDK4 kinase function in breast cancer. Cancer Cell 9,23-32 (2006).

    • E. Sicinska, I. Aifantis, L. Le Cam, W. Swat, C. Borowski, Q. Yu, A.A. Ferrando, S.D. Levin, Y. Geng, H. von Boehmer, P. Sicinski. Requirement for cyclin D3 in lymphocyte development and T-cell leukemias. Cancer Cell 4, 292-295 (2003).

    • J. Odajima, Z.P. Wills, Y.M. Ndassa, M. Terunuma, K. Kretschmannova, T.Z. Deeb, Y. Geng, S. Gawrzak, I.M. Quadros, J. Newman, M. Das, M.E. Jecrois, Q. Yu, N. Li, F. Bienvenu, S.J. Moss, M.E. Greenberg, J.A. Marto, P. Sicinski. Cyclin E constrains Cdk5 activity to regulate synaptic plasticity and memory formation. Dev Cell 21(4), 655-68 (2011).
    • L. Anders, N. Ke, P. Hydbring, Y.J. Choi, H.R. Widlund, J.M. Chick, H. Zhai, M. Vidal, S.P. Gygi, P. Braun, P. Sicinski. A systematic screen for CDK4/6 substrates links FOXM1 phosphorylation to senescence suppression in cancer cells. Cancer Cell 20(5), 620-34 (2011).
    • S. Jirawatnotai, Y. Hu, W. Michowski, J.E. Elias, L. Becks, F. Bienvenu, A. Zagozdzon, T. Goswami, Y.E. Wang, A.B. Clark, T.A. Kunkel, T. van Harn, B. Xia, M. Correll, J. Quackenbush, D.M. Livingston, S.P. Gygi, P. Sicinski. A function for cyclin D1 in DNA repair uncovered by protein interactome analyses in human cancers. Nature 474(7350), 230-4 (2011).
    • Y.J. Choi, X. Li, P. Hydbring, T. Sanda, J. Stefano, A.L. Christie, S. Signoretti, A.T. Look, A.L. Kung, H. von Boehmer, P. Sicinski. The requirement for cyclin D function in tumor maintenance. Cancer Cell 22(4), 438-51 (2012).

    Investigators

    • Geng, Yan, MD, PhD

    Trainees

    • Odajima, Junko, PhD
    • Jirawatnotai, Siwanon, PhD
    • Choi, Yoon, PhD
    • Hydbring, Per, PhD
    • Michowski, Wojciech, PhD
    • Otto, Tobias, PhD
    • Liu, Lijun, MD
    • Wang, Haizhen, Ph.D.
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