• Researcher Profile

    William C. Hahn, MD, PhD

    Chief Research Strategy Officer
    Chair, Executive Committee for Research
    Chief, Division of Molecular and Cellular Oncology

    Professor of Medicine, Harvard Medical School
    Institute Member, Broad Institute of Harvard and MIT


    Genitourinary Oncology

    Office phone: 617-632-3155
    Fax: 617-632-2165
    Website: hahnlab.org

    View Physician Profile

    Research Department

    Medical Oncology/Molecular and Cellular


    Prostate cancer

    Area of Research

    Functional genomics and human cell transformation, Precision cancer medicine

    Dana-Farber Cancer Institute
    450 Brookline Avenue
    Dana 1538
    Boston, MA 02215


    Dr. Hahn received his MD and PhD from Harvard Medical School in 1994. He then completed clinical training in internal medicine at Massachusetts General Hospital and medical oncology at DFCI. He conducted his postdoctoral studies with Dr. Robert Weinberg at the Whitehead Institute and joined the faculty of DFCI and Harvard Medical School in 2001.

    Recent Awards

    • Elected to Association of American Physicians, 2013
    • Ho-Am Laureate in Medicine, 2010
    • Gill-Simonian Prize for Mentoring, 2008
    • Elected to the American Society of Clinical Investigation, 2005
    • Wilson S. Stone Memorial Award, MD Anderson Cancer Center, 2000


    Functional genomics and human cell transformation, Precision cancer medicine

    My work as a physician-scientist involves both the care of cancer patients and biomedical research directed toward a greater understanding of the mechanisms involved in malignant transformation. My laboratory focuses on understanding the cooperative interactions that conspire to transform human cells. To address this question, we have developed new experimental models of human cancer of defined genetic composition, created methods to perform systematic interrogation of gene function in mammalian cells and tissues and help optimize new approaches to integrate genome scale data. Using these approaches, we have identified and credential new oncogenes and tumor suppressor genes and have performed preclinical studies that will form the foundation necessary for translational studies in patients.

    Specifically, we have developed genetic methods that permit the construction of genetically defined, experimental models of the major human epithelial cancers from primary human cells through the manipulation of oncogenes, tumor suppressor genes and telomerase. These model systems have permitted us to study the molecular interactions that lead to cancer. In addition, we have performed proof-of-principle experiments that such experimental models will prove useful in the discovery and validation of molecularly targeted therapies. Indeed, these experimental models have allowed us to investigate the mechanisms by which EGFR and other oncogenes and tumor suppressors contribute to cancer initiation. In particular, we have elucidated the role of the PP2A family of serine-threonine phosphatases as tumor suppressor genes.

    As a Senior Associate Member of the Broad Institute, I lead efforts to apply functional genomic approaches to cancer. Specifically, I serve as one of the co-principal investigators for the RNAi Consortium (TRC), which has created a genome scale RNA interference library, and have established RNAi screening facilities at both the Broad Institute and the Dana-Farber Cancer Institute (DFCI). In my own laboratory, we are engaged in using these RNAi libraries to apply a comprehensive program to identify cancer vulnerabilities. Using these approaches, we have already discovered several new oncogenes including IKBKE, CDK8, CRKL, CDK6, and PAK1. I also co-direct the Center for Cancer Genome Discovery, which is committed to the development and implementation of technologies that permit the interrogation of cancer-associated mutations at genome scale and to implement these technologies prospectively in newly diagnosed patients.



    • Hagerstrand, Daniel, PhD
    • Wang, Xiaoxing, PhD
    • Shao, Diane, BS (MD-PhD student)
    • O'Connell, Joyce T, PhD
    • Ilic, Nina, PhD
    • Hong, Andrew, MD
    • Spardy, Nicole, PhD
    • Aguirre, Andrew, MD, PhD
    • Zwang, Yaara, PhD
    • Krall, Elsa B, PhD
    • Giacomelli, Andrew, MS (grad student)
    • Wang, Belinda, BS (MD-PhD student)
    • Kim, Eejung, MD (grad student)
    • Abudayyeh, Omar, BS (MD-PhD student)
    • Li, Ji, PhD
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