Eva C. Guinan, MD
Professor of Pediatrics, Harvard Medical School
Center/ProgramPediatric Cancer Survivorship
Office phone: 617-632-4932
Preferred contact method: email
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Hematopoietic stem cell transplantation, Bone marrow failure disorders, Aplastic anemia, Myelodysplasia, Regimen-related toxicity
Area of ResearchInduction of Anergy by Costimulatory Blockade
Dana-Farber Cancer Institute
450 Brookline Avenue
Boston, MA 02215
BiographyDr. Guinan received her MD from Harvard Medical School in 1980, followed by a pediatric residency at Children's Hospital and a pediatric hematology-oncology fellowship at Children's Hospital and DFCI. She was appointed associate director of the Bone Marrow Transplant Service in 1990 and directed the program from 1997 through 2005. She assumed a new position in 2005 as the Associate Director of the Center for Clinical and Translational Research. Her own translational research program focuses on the costimulatory blockade as a mechanism of overcoming problems related to allogenicity in transplantation and the amelioration of regimen-related toxicity.
- Distinguished Service Award from the Fanconi Anemia Research Foundation, 2009
- Clare and Richard Morse Research Award, 2000
- Clinical Translational Scientist Award, Burroughs Wellcome, 1999
ResearchInduction of Anergy by Costimulatory Blockade
Our research focuses on overcoming problems related to allogenicity in transplantation.
Allogeneic transplantation is limited, in large part, by the ability to find donors of suitable histocompatibility. Global immunosuppression has been an incomplete and highly toxic approach to this problem. Current understanding of T cell activation suggests that blocking B7-CD28 interactions of the costimulatory pathway for human T helper cells may provide both antigen-specific T cell hyporesponsiveness and active suppression of alloantigen specific immunity. We are applying these various strategies to the transplant setting and investigating other approaches to improve immunity after transplantation.
Another area of active investigation is the mitigation of regimen-related toxicity during transplantation and/or chemotherapy. We are investigating novel agents for prevention or treatment of regimen-related toxicity, with a focus on mitigating radiation toxicity.
In another area of investigation, we are examining the role of distributed problem solving techniques in generating, evaluating and maintaining innovation in healthcare related research.
- Davies, Jeff