Shuji Ogino, MD, PhD, MS
Professor, Department of Epidemiology, Harvard T.H. Chan School of Public Health
Office phone: 617-632-1972
Website: Ogino Lab
Preferred contact method: email
View Physician Profile
Area of Research
Molecular Pathological Epidemiology (MPE, Molecular Pathologic Epidemiology), Epigenetics, Epigenomics, Colorectal cancer, Gastrointestinal cancer
Dana-Farber Cancer Institute
450 Brookline Avenue
Boston, MA 02215
Other Practice Locations
Brigham and Women's Hospital
75 Francis Street
Boston, MA 02215
Dr. Ogino received his MD in 1993 and his PhD in 2001 from the University of Tokyo, Japan. He completed his residency in anatomic pathology and clinical pathology at Case Western Reserve University and University Hospitals Case Medical Center in 1999, and a molecular pathology fellowship in 2000 at the University of Pennsylvania. After a postdoctoral fellowship, he joined Dana-Farber Cancer Institute as Instructor in 2001. Dr. Ogino was promoted to Associate Professor of Pathology in 2008, and received secondary faculty appointment at Harvard School of Public Health (Associate Professor in the Department of Epidemiology) in 2012. Dr. Ogino also serves as a pathologist at Brigham and Women's Hospital. Dr. Ogino received the Ramzi Cotran Young Investigator Award from United States and Canadian Academy of Pathology (USCAP) in 2011; and Meritorious Service Award from Association for Molecular Pathology (AMP); in recognition of his pioneering effort and service to establish the interdisciplinary and integrative field of Molecular Pathological Epidemiology (MPE).
- Meritorious Service Award, from Association for Molecular Pathology (AMP), October 2012
- Ramzi Cotran Young Investigator Award, from United States and Canadian Academy of Pathology (USCAP), March 2011
ResearchMolecular Pathological Epidemiology (MPE, Molecular Pathologic Epidemiology), Epigenetics, Epigenomics, Colorectal cancer, Gastrointestinal cancer
(For full description, please visit http://www.hsph.harvard.edu/shuji-ogino/ )
The relationship between exposures and tumor molecular changes has been examined (eg, smoking -> KRAS mutation), under the umbrella of "molecular epidemiology". However, this type of analysis needs a consideration of disease heterogeneity (eg, KRAS mutation present vs. absent), which necessitates a paradigm shift from conventional epidemiology, which is based on the premise that individuals with a given disease (by name) are homogeneous and can be lumped together to analyze the associations with exposures.
- Schernhammer ES, Giovannucci E, Kawasaki T, Rosner B, Fuchs CS, Ogino S. Dietary folate, alcohol, and B vitamins in relation to LINE-1 hypomethylation in colon cancer. Gut 2010: in press (published online).
- Nosho K, Kure S, Irahara N, Shima K, Baba Y, Spiegelman D, Meyerhardt JA, Giovannucci EL, Fuchs CS, Ogino S. A prospective cohort study shows unique epigenetic, genetic, and prognostic features of synchronous colorectal cancers. Gastroenterology 2009: in press (published online).
- Chan AT, Ogino S, Fuchs CS. Aspirin use and survival after diagnosis of colorectal cancer. JAMA J Am Med Assoc 2009;302:649-658.
- Ogino S, Nosho K, Irahara N, Shima K, Baba Y, Kirkner GJ, Meyerhardt JA, Fuchs CS. Prognostic significance and molecular associations of 18q loss of heterozygosity: a cohort study of microsatellite stable colorectal cancers. J Clin Oncol 2009;27:4591-4598.
- Ogino S, Shima K, Baba Y, Nosho K, Irahara N, Kure S, Chen L, Toyoda S, Kirkner GJ, Wang YL, Giovannucci EL, Fuchs CS. Colorectal cancer expression of peroxisome proliferator-activated receptor-gamma; (PPARG, PPARgamma) is associated with good prognosisis. Gastroenterology 2009;136:1242-1250. PMCID:PMC2663601
- Ogino S, Nosho K, Kirkner GJ, Shima K, Irahara N, Kure S, Chan AT, Engelman JA, Kraft P, Cantley LC, Giovannucci EL, Fuchs CS. PIK3CA mutation is associated with poor prognosis among patients with curatively resected colon cancer. J Clin Oncol 2009;27:1477-1484. PMCID:PMC2659340
- Ogino S, Nosho K, Kirkner GJ, Kawasaki T, Meyerhardt JA, Loda M, Giovannucci EL, Fuchs CS. CpG island methylator phenotype, microsatellite instability, BRAF mutation and clinical outcome in colon cancer. Gut 2009;58:90-6. PMCID:PMC2679586
- Ogino S, Nosho K, Meyerhardt JA, Kirkner GJ, Chan AT, Kawasaki T, Giovannucci EL, Loda M, Fuchs CS. Cohort study of fatty acid synthase expression and patient survival in colon cancer. J Clin Oncol 2008;26:5713-20. PMCID:PMC2630484
- Ogino S, Nosho K, Kirkner GJ, Kawasaki T, Chan AT, Schernhammer ES, Giovannucci EL, Fuchs CS. A cohort study of tumoral LINE-1 hypomethylation and prognosis in colon cancer. J Natl Cancer Inst 2008;100:1734-8. PMCID:PMC2639290
- Nosho K, Irahara N, Shima K, Kure S, Kirkner GJ, Schernhammer ES, Hazra A, Hunter DJ, Quackenbush J, Spiegelman D, Giovannucci EL, Fuchs CS, Ogino S. Comprehensive biostatistical analysis of CpG island methylator phenotype in colorectal cancer using a large population-based sample. PLoS ONE 2008;3:e3698. PMCID:PMC2579485.
- Schernhammer ES, Ogino S, Fuchs CS. Folate intake and risk of colon cancer in relation to p53 expression. Gastroenterology 2008;135:770-80. PMCID:PMC2634965
- Firestein R, Bass AJ, Kim SY, Dunn IF, Silver SJ, Guney I, Freed E, Ligon AH, Vena N, Ogino S, Chheda MG, Tamayo P, Finn S, Shrestha Y, Boehm JS, Jain S, Bojarski E, Mermel C, Barretina J, Chan JA, Baselga J, Tabernero J, Root DE, Fuchs CS, Loda M, Shivdasani RA, Meyerson M, Hahn WC. CDK8 is a colorectal cancer oncogene that regulates beta-catenin. Nature 2008;455:547-51. PMCID:PMC2587138
- Ogino S, Kawasaki T, Kirkner GJ, Suemoto Y, Meyerhardt JA, Fuchs CS. Molecular correlates with MGMT promoter methylation and silencing support CpG island methylator phenotype-low (CIMP-low) in colorectal cancer. Gut 2007;56:1564-71.
- Chan AT, Ogino S, Fuchs CS. Aspirin use and risk of colorectal cancer according to cyclooxygenase-2 expression. New Engl J Med 2007;356:2131-42.
- Ogino S, Cantor M, Kawasaki T, Brahmandam M, Kirkner GJ, Weisenberger DJ, Campan M, Laird PW, Loda M, Fuchs CS. CpG island methylator phenotype (CIMP) of colorectal cancer is best characterised by quantitative DNA methylation analysis and prospective cohort studies. Gut 2006;55:1000-6.
- Ogino S, Nosho K, Irahara N, Shima K, Baba Y, Kirkner GJ, Mino-Kenudson M, Giovannucci EL, Meyerhardt JA, Fuchs CS. Negative lymph node count is associated with survival of colorectal cancer patients, independent of tumoral molecular alterations and lymphocytic reaction. Am J Gastroenterol 2010;105:420-433.
- Firestein R, Shima K, Nosho K, Irahara N, Baba Y, Bojarski E, Giovannucci EL, Hahn WC, Fuchs CS, Ogino S. CDK8 expression in 470 colorectal cancers in relation to -catenin activation, other molecular alterations and patient survival. Int J Cancer 2010: in press (published online).
- Irahara N, Nosho K, Baba Y, Shima K, Lindeman NI, Hazra A, Schernhammer ES, Hunter DJ, Fuchs CS, Ogino S. Precision of Pyrosequencing assay to measure LINE-1 methylation in colon cancer, normal colonic mucosa and peripheral blood cells. J Mol Diagn 2010;12:177-183.
- Baba Y, Nosho K, Shima K, Irahara N, Chan AT, Meyerhardt JA, Chung DC, Giovannucci EL, Fuchs CS, Ogino S. HIF1A overexpression is associated with poor prognosis in a cohort of 731 colorectal cancers. Am J Pathol 2010: in press.
- Baba Y, Nosho K, Shima K, Goessling W, Chan AT, Ng K, Chan JA, Giovannucci EL, Fuchs CS, Ogino S. PTGER2 overexpression in colorectal cancer is associated with microsatellite instability, independent of CpG island methylator phenotype. Cancer Epidemiol Biomarkers Prev 2010;19:822-831.
- Worthley DL, Whitehall VLJ, Buttenshaw RL, Irahara N, Greco SA, Ramsnes I, Mallitt K, Le Leu RK, Winter J, Hu Y, Ogino S, Young GP, Leggett BA. DNA methylation within the normal colorectal mucosa is associated with pathway specific predisposition to cancer. Oncogene 2010: in press.
- Ogino S, Stampfer M. Lifestyle factors and microsatellite instability in colorectal cancer: the evolving field of molecular pathological epidemiology [editorial]. J Natl Cancer Inst 2010: in press (published online).
- Imamura, Yu, MD, PhD
- Liao, Xiaoyun, MD, PhD
- Qian, Zhirong, MD, PhD
- Kuchiba, Aya, PhD
- Yamauchi, Mai, PhD
- Nishihara, Reiko, PhD
- Jung, Seungyoun, ScD
- Inamura, Kentaro, MD, PhD
- Kim, Sun A., MD, PhD
- Sukawa, Yasutaka, MD, PhD
- Mima, Kosuke, MD, PhD
- Fitzgerald, Kathryn, MS