Peter Sicinski, MD, PhD
Office phone: 617-632-5005
Preferred contact method: email
Area of ResearchCell Cycle Machinery in Development and Cancer
Dana-Farber Cancer Institute
450 Brookline Avenue
Boston, MA 02215
Dr. Sicinski received his MD and PhD from the Warsaw Medical School in Poland. He spent two years as a visiting scientist at the Medical Research Council in Cambridge, England, before becoming a postdoctoral fellow with Dr. Robert A. Weinberg at Massachusetts Institute of Technology.
In 1997, Dr. Sicinski joined the faculty of Harvard and Dana-Farber Cancer Institute, where his research focuses on genes in the cell cycle machinery involved in normal cell development and cancer.
- Foreign Member, Polish Academy of Sciences, 2005
- Scholar of the Leukemia & Lymphoma Society, 2005
- Scholar Leukemia & Lymphoma Society Award,, 2003
- AACR-Gertrude B. Elion Cancer Research Award, 2002
- Abbott Bioresearch Center Award, 2002
ResearchCell Cycle Machinery in Development and Cancer
The cell cycle machinery is the ultimate recipient of oncogenic and mitogenic signals.
Our laboratory studies the function of the cell cycle machinery at a molecular, cellular and organismal levels. We generated several knock-out and knock-in mouse strains which allow us to dissect the function of cell cycle proteins in normal development and in cancer formation or progression.
We are also developing novel strains of mice that allow proteomic approaches to study the functions of cell cycle proteins (including cell cycle-independent functions) in various tissues of the living animal. The broad goal of these new directions is to combine the techniques of mouse germline manipulation with the new methods of proteome- and genome-wide analyses. We are also focusing on the functioning of the cell cycle machinery in various stem cell compartments.
An important direction of our studies is to analyze the molecular functions of cell cycle proteins in human cancers.
- F. Bienvenu, S. Jirawatnotai, J.E. Elias, C.A. Meyer, K. Mizeracka, A. Marson, G.M. Frampton, M.F. Cole, D.T. Odom, J. Odajima, Y. Geng, A. Zagozdzon, M. Jecrois, R.A. Young, X.S. Liu, C.L. Cepko, S.P. Gygi, P. Sicinski. Transcriptional role of cyclin D1 in development revealed by a genetic-proteomic screen. Nature 463(7279), 374-8 (2010).
- I. Kalaszczynska, Y. Geng, T. Iino, S. Mizuno, Y. Choi, I. Kondratiuk, D.P. Silver, D.J. Wolgemuth, K. Akashi, P. Sicinski. Cyclin A Redundant in fibroblasts, essential in hematopoietic and embryonal stem cells. Cell 138(2), 352-65 (2009).
- G. Das, Y. Choi, P. Sicinski, E.M. Levine. Cyclin D1 fine-tunes the neurogenic output of embryonic retinal progenitor cells. Neural Dev 4(1), 15 (2009).
- Y. Geng, Y.M. Lee, M. Welcker, J. Swanger, A. Zagozdzon, J.D. Winer, J.M. Roberts, P. Kaldis, B.E. Clurman, P. Sicinski. Kinase-independent function of cyclin E. Mol. Cell 25, 127-39 (2007).
- E. Sicinska, Y.M. Lee, J. Gits, H. Shigematsu, Q. Yu, V.I. Rebel, Y. Geng, C.J. Marshall, K. Akashi, D.M. Dorfman, I.P. Touw, P. Sicinski. Essential role for cyclin D3 in granulocyte colony-stimulating factor-driven expansion of neutrophil granulocytes. Mol. Cell. Biol. 26(21), 8052-60 (2006).
- M.W. Landis, B.S. Pawlyk, T. Li, P. Sicinski, P.W. Hinds. Cyclin D1-dependent kinase activity in murine development and mammary tumorigenesis. Cancer Cell 9, 13-22 (2006).
- K. Kozar, M. Ciemerych, V. Rebel, H. Shigematsu, A. Zagozdzon, E. Sicinska, Y. Geng, Q. Yu, S. Bhattacharya, R. Bronson, K. Akashi, P. Sicinski. Mouse development and cell proliferation in the absence of D-cyclins. Cell 118, 477-491 (2004).
- Y. Geng, Q. Yu, E. Sicinska, M. Das, J.E. Schneider, S. Bhattacharya, W.M. Rideout, R.T.Bronson, H. Gardner, P. Sicinski. Cyclin E ablation in the mouse. Cell 114, 431-443 (2003).
- P. Sicinski, S. Zacharek, C. Kim. Duality of p27Kip1 function in tumorigenesis. Genes Dev. 21(14),1403-6 (2007).
- Q. Yu, E. Sicinska, Y. Geng, M. Ahnstrom, A. Zagozdzon, Y. Kong, H. Gardner, H. Kiyokawa, L.N. Harris, O. Stal, P. Sicinski. Requirement for CDK4 kinase function in breast cancer. Cancer Cell 9,23-32 (2006).
- B.C. Carthon, C.A. Neumann, M. Das, B. Pawlyk, T. Li, Y. Geng, P. Sicinski. Genetic replacement of cyclin D1 function in mouse development by cyclin D2. Mol. Cell. Biol. 25, 1081-1088 (2005).
- E. Sicinska, I. Aifantis, L. Le Cam, W. Swat, C. Borowski, Q. Yu, A.A. Ferrando, S.D. Levin, Y. Geng, H. von Boehmer, P. Sicinski. Requirement for cyclin D3 in lymphocyte development and T-cell leukemias. Cancer Cell 4, 292-295 (2003).
- Geng, Yan, MD, PhD
- Odajima, Junko, PhD
- Anders, Lars, PhD
- Jirawatnotai, Siwanon, PhD
- Choi, Yoon, PhD
- Hydbring, Per, PhD
- Michowski, Wojciech, PhD
- Otto, Tobias, PhD
- Li, Na, PhD
- Liu, Lijun, MD