Lisa R. Diller, MD
Clinical Director, Pediatric Oncology
Medical Director, Clinical Cancer and Blood Disorders Service Line
Medical Director, Perini Clinic
Professor of Pediatrics, Harvard Medical School
Centers/ProgramsPediatric Solid Tumors
Pediatric Cancer Survivorship
Office phone: 617-632-5642
Preferred contact method: office phone
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Late effects of pediatric cancer, Retinoblastoma, Solid tumors, Wilms tumor, Neuroblastoma, Cancer predisposition
Area of ResearchNeuroblastoma and Cancer Survivorship
Dana-Farber Cancer Institute
450 Brookline Avenue
Shields Warren 312
Boston, MA 02215
Dr. Lisa Diller is the Chief Medical Officer, Dana-Farber/Boston Children's Cancer and Blood Disorders Center. As a pediatric oncologist and the Clinical Director of Pediatric Oncology, she leads the joint clinical Pediatric Oncology Program at the Dana-Farber Cancer Institute and Boston Children's Hospital. She is also the Director of the Perini Family Survivors Center and the David B. Perini, Jr. Quality of Life Clinic for Cancer Survivors at Dana-Farber. She is a Professor of Pediatrics at Harvard Medical School. Dr. Diller received a bachelors degree from Harvard University, and earned her medical degree from the University of California at San Diego. She was a resident at Boston Children's Hospital and did her subspecialty training at Boston Children's Hospital/Dana-Farber Institute where she has been on the faculty for 19 years. Dr. Diller's research focuses on the late effects of treatment for childhood cancer and genetic cancer predisposition syndromes in childhood. In addition, she investigates novel treatments for pediatric solid tumors, particularly tumors that occur in infants and toddlers.
- Stephen E. Sallan Leadership award, 2004
- Benacerraf-Frei Investigator, DFCI, 1998
- Dyson Scholar Award, DFCI, 1998
ResearchNeuroblastoma and Cancer Survivorship
The focus of our research is in two major areas: the treatment of patients with solid tumors - notably neuroblastoma and Wilms' tumor - and the study of survivors of childhood cancer.
In treating patients with neuroblastoma, our approach has been to intensify therapy using high-dose therapy in tandem with stem cell rescue. In addition, we are studying new approaches to the treatment of minimal residual neuroblastoma, including antiangiogenic agents, demethylating agents, and immunomodulatory approaches. (We are participants in the New Agents in Neuroblastoma Therapy consortium.) Studies of survivors of neuroblastoma are also under way.
In research on medical late effects, we have been studying young adult patients with a history of cancer treatment, hoping to delineate the morbidity of a variety of therapies and to introduce screening and prevention in this group of patients. We also have completed an early mammography trial after chest irradiation, showing that women who were treated with chest radiation are at significant risk of breast cancer and that mammography detects early tumors in this cohort. A prevention trial using tamoxifen for these women is in analysis.
Moreover, we are active participants in the largest childhood cancer survivor cohort study, the Childhood Cancer Survivor Study, involving 24 centers and over 17,000 survivors. We have completed an analysis of breast cancers in that cohort, and are studying risk factors for secondary sarcomas. Interventional studies using the same cohort are under way, including a web-based smoking cessation intervention, an analysis of breast cancer screening behaviors, and a planned study of renal disease screening.
- Diller L, Chow EJ, Gurney JG, Hudson MM, Kadin-Lottick NS, Kawashima TI, Leisenring WM, Meacham LR, Mertens AC, Mulrooney DA, Oeffinger KC, Packer RJ, Robison LL, Sklar CA. Chronic disease in the Childhood Cancer Survivor Study cohort: a review of published findings. J Clin Oncol. 2009 May 10;27(14):2339-55.
- Laverdire C, Liu Q, Yasui Y, Nathan PC, Gurney JG, Stovall M, Diller L, Cheung NK, Wolden S, Robison LL, Sklar CA. Long-term outcomes in survivors of neuroblastoma: A Report from the Childhood Cancer Survivor Study. J Natl Cancer Inst. 2009 Aug 19;101(16):1131-40.
- Oeffinger KC, Ford JS, Moskowitz CS, Diller L, Hudson MM, Chou JF, Smith SM, Mertens AC, Henderson TO, Friedman DL, Leisenring WM, Robison LL. Breast cancer surveillance practices among women previously treated with chest radiation for a childhood cancer: A Report from the Childhood Cancer Survivor Study (CCSS). JAMA. 2009 Jan 28; 301(4): 404-14.
- Inskip PD, Robison LL, Stovall M, Smith SA, Hammond S, Mertens AC, Whitton JA, Diller L, Kenney L, Donaldson SS, Meadows AT, Neglia JP. Radiation Dose and Breast Cancer Risk in Childhood Cancer Survivor Study. J Clin Oncol. 2009 Aug 20:27(24):3901-7.
- Kenney LB, Medeiros-Nancarrow C, Najita J, Vrooman L, Rothwell M, Recklitis C, Li F, Diller L. Health Status of the oldest adult survivors of cancer during childhood. Cancer. 2010 Jan 15;116(2): 497-505.
- Henderson TO, Hlubocky FJ, Kasza KK,.Diller L, Daugherty CK. Physician Preferences and Knowledge Gaps Regarding the Care of Childhood Cancer Survivors: A Mailed Survey of Pediatric Oncologists. J Clin Oncol. 2010 Feb 10;28(5);878-83.
- Bober SL, Recklitis CJ, Campbell EG, Park ER, Kutner JS, Najita JS, Diller L, Caring for cancer survivors: a survey of primary care physicians. Cancer. 2009 Sept 15;115(18 Suppl):4409-18.
- DuBois SG, London WB, Zhang Y, Matthay KK, Monclair T, Ambros PF, Cohn SL, Pearson AP, Diller L. Lung Metastases in Neuroblastoma at Initial Diagnosis: A Report from the International Neuroblastoma Risk Group (INRG) Project. Pediatrics Blood and Cancer. 2008 July (51):589-592.
- Henderson T, Whitton J, Stovall M, Mertens AC, Mitby P, Friedman D, Strong L, Hammond S, Neglia JP, Meadows AT, Robison LL, Diller L. Secondary sarcomas in childhood cancer survivors: A report from the Childhood Cancer Survivor Study. Journal of the National Cancer Institute. 2007 Feb 99 (4):300-8.