• Researcher Profile

    David S. Pellman, MD

    Margaret M. Dyson Professor of Pediatric Oncology
    Professor of Cell Biology, Harvard Medical School
    Investigator, Howard Hughes Medical Institute

    Office phone: 617-632-4918
    Fax: 617-632-6845
    Email: david_pellman@dfci.harvard.edu

    Preferred contact method: email

    Research Department

    Pediatric Oncology

    Area of Research

    Cell Division and Genome Stability

    Dana-Farber Cancer Institute
    450 Brookline Avenue
    Mayer 663
    Boston, MA 02215


    Dr. Pellman received his MD in 1986 from the University of Chicago, Pritzker School of Medicine, and did postgraduate training in pediatrics and pediatric hematology-oncology at DFCI and Children's Hospital, Boston. He was a postdoctoral fellow at the Whitehead Institute for Biomedical Research at Massachusetts Institute of Technology. In 1995, he joined DFCI, and is currently the Margaret M. Dyson Professor of Pediatric Oncology, Professor of Cell Biology, Harvard Medical School. In 2008, he was appointed as an Investigator of the Howard Hughes Medical Institute.

    Recent Awards

    • AAAS Fellow, Medical Sciences, 2012
    • Association of American Physicians, 2010
    • American Pediatric Society (APS), 2008
    • HHMI, Investigator, 2008
    • E. Mead Johnson Award, Society of Pediatric Research, 2006
    • Stohlman Scholar, Leukemia and Lymphoma Society, 2005
    • American Society for Clinical Investigation, 2001
    • BASF Bioresearch Award, DFCI, 2001
    • Scholar Award, Leukemia & Lymphoma Society, 2000
    • Graduate Student Mentoring Award, Harvard Medical School, 1999
    • Kimmel Scholar Award, 1998
    • Damon Runyon Scholar Award, 1996
    • Claudia Adams Barr Investigator, DFCI, 1994
    • NIH Clinical Investigator Award, 1992
    • St. Jude's Children's Hospital Fellow in the Pediatric Scientist Training Program, 1989
    • Alpha Omega Alpha Research Fellowship, 1986
    • Catherine Dobson Prize for Research; University of Chicago, Pritzker School of Medicine, 1986


    Cell Division and Genome Stability

    Our laboratory aims to understand normal cell division mechanisms and to discover cell division defects that are unique to cancer cell.  We take a range of approaches including genetics, functional genomics, biochemistry and live cell imaging. There are ongoing projects using yeast, tissue culture cells, and genetically engineered mice.

    Our work on cytoskeletal dynamics is focused on the mechanism of chromosome segregation in normal cells and cancer cells. We are particularly interested in how the microtubule and actin cytoskeletons interact and how cell cycle signals remodel these cytoskeletal systems.  For example, we have recently uncovered a mechanism by which actin organization and the adhesive microenvironment of cells influence chromosome segregation. We study how centrosome amplification in cancer cells impacts cellular adhesion, cell migration, and tumor invasion. We have discovered new drug targets that kill cancer cells because of their centrosome amplification.  We have defined cytoskeletal mechanisms that control polarized cell growth, asymmetric cell division, and cytokinesis. We use biochemical and imaging approaches to understand these processes at a mechanistic level.

    We are also interested in how aneuploidy (abnormal chomosome number) and polyploidy (increased sets of chromosomes) impact on tumor biology. We have developed new methods to generate human cells with specific cancer-associated trisomies and are studying how these trisomies impact tumorigenesis.  We discovered that failure of cytokinesis, which doubles the number of chromosomes and centrosomes, promotes tumorigenesis, using a mouse breast cancer model. We recently identified a mechanism by which errors in mitosis cause DNA breaks. These findings may explain the recently discovered phenomenon of chromothripsis, where a single chromosome or chromosome arm appears to undergo massive breakage and rearrangement.  


    • Kwon, Mijung, PhD
    • Selmecki, Anna, PhD
    • Gordon, David, MD, PhD
    • Chiu, Shang-Yi, PhD
    • Cornils, Hauke, PhD
    • Stokasimov, Ema, PhD
    • Picone, Remigio, PhD
    • Varetti, Gianluca, PhD
    • Kaplan-Dor, Yosef, PhD
    • Spector, Alex, MD, PhD
View Physician Directory

Find a Clinical Trial

Support Cancer

Give Now