Michael Goldberg, Ph.D.
Office phone: 617-582-9840
Preferred contact method: email
Area of Research
Development and Delivery of Novel Therapeutics to Address Cancer
Dana-Farber Cancer Institute
450 Brookline Avenue
Boston, MA 02215
BiographyDr. Goldberg received his PhD in 2008 from MIT, where he worked in the laboratory of Institute Professor Robert Langer. He subsequently pursued post-doctoral training under the supervision of Institute Professor Philip Sharp at MIT. In 2012, he became assistant professor of Microbiology and Immunobiology at Harvard Medical School and in the Department of Cancer Immunology at Dana-Farber Cancer Institute, where he works on the development and delivery of novel therapeutics.
ResearchDevelopment and Delivery of Novel Therapeutics to Address Cancer
Our laboratory is interested to develop and deliver novel therapeutics to address cancer. Cancer is a leading cause of death worldwide, and -- unlike other leading causes of death such as heart disease and infectious disease -- its incidence is increasing. Indeed, cancer is now the primary cause of death among Americans under the age of 85. Conventional therapeutic approaches involve harsh treatment regimens that entail severe side effects. Clearly, the establishment of disruptive therapeutic molecules and platforms would be desirable.
The ability to regulate the expression of specific genes either positively or negatively in specific cells in animal models and in patients would be of great utility. To this end, our laboratory seeks to develop targeted systems for the delivery of mRNA and RNAi therapeutics. These molecules provde the tremendous specificity of genetic therapies but, owing to their impermanence, allow for dosage control like traditional therapeutic modalities. By combining applied chemical tools with an understanding of basic RNA biology and immunology, we aim to generate innovative technologies.
Indeed, through evolution, the immune system has been selected to serve as the greatest drug delivery system developed to date. By modulating genes encoding stimulatory and inhibitory signals, we will attempt to leverage the host immune system's ability to expand, to communicate with complementary cell types, to penetrate deeply into tumor parenchyma, and to develop a memory response. This strategy is designed to be as broadly applicable as possible as it is indifferent to the type of cancer and its underlying mutations.
Three current areas of research in the lab are:
I) Targeting RNA delivery to specific immune cells
II) Generating improved cancer vaccines
III) Developing tumor-homing and tumor-penetrating drug delivery systems
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